WBP2 (WW domain-binding protein 2) is a steroid hormone receptor coactivator. This protein contains 1 GRAM domain. The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. It binds to the WW domain of Yes kinase-associated protein (YAP1) by its PY motifs. The WW-binding 1 motif mediates interaction with NEDD4. Source: Recombinant protein corresponding to aa1-261 from human WBP2, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~30.5kD (284aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMALNKNH SEGGGVIVNN TESILMSYDH VELTFNDMKN VPEAFKGTKK GTVYLTPYRV IFLSKGKDAM QSFMMPFYLM KDCEIKQPVF GANYIKGTVK AEAGGGWEGS ASYKLTFTAG GAIEFGQRML QVASQASRGE VPSGAYGYSY MPSGAYVYPP PVANGMYPCP PGYPYPPPPP EFYPGPPMMD GAMGYVQPPP PPYPGPMEPP VSGPDVPSTP AAEAKAAEAA ASAYYNPGNP HNVYMPTSQP PPPPYYPPED KKTQ Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
