MIP-3alpha is a CC chemokine, expressed in the liver, lymph nodes, appendix, PBL and lungs that can signal through the CCR6 receptor. MIP-3alpha is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells, and inhibits colony formation of bone marrow myeloid immature progenitors. Recombinant human MIP-3alpha is an 8kD protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Recombinant protein corresponding to human CCL20, expressed in E. coli. Molecular Weight: ~8kD Biological Activity: Determined by its ability to chemoattract human T lymphocytes using a concentration range of 10-50ng/ml Amino Acid Sequence: ASNFDCCLGY TDRILHPKFI VGFTRQLANE GCDINAIIFH TKKKLSVCAN PKQTWVKYIV RLLSKKVKNM Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplied as a lyophilized powder in PBS Reconstitute with sterile ddH2O to 0.1-1mg/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
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