OTOR, also called Otoraplin and MIAL, is a secreted cytokine and a member of the MIA/OTOR family. Members of this family which also includes MIA, MIA2, and TANGO share a Src homology-3 (SH3)-like domain. OTOR is predominantly expressed in the cochlea of the inner-ear and to a lesser extent in fetal brain and in some cartilage tissues. OTOR appears to be involved in early chondrogenesis of the otic capsule, which is required for normal inner ear development and auditory function. Recombinant protein corresponing to 112aa from human OTOR, expressed in E. coli. Accession/Uniport: Q9NRC9. Molecular Weight: ~12.7kD (112aa) Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Amino Acid Sequence: MVHGIFMDRL ASKKLCADDE CVYTISLASA QEDYNAPDCR FINVKKGQQI YVYSKLVKENGAGEFWAGSV YGDGQDEMGV VGYFPRNLVK EQRVYQEATK EVPTTDIDFF CE Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
