RETNLb (Resistin Like Beta, XCP2, FIZZ2, HXCP2, CCRG, RETNL2, RELMb, Foundin In Flammatory Zone 2, Colon and small intestine-specific cysteine-rich protein, Colon carcinoma-related gene protein), Rabbit
Biozol Catalog Number:
USB-364895
Supplier Catalog Number:
364895
Alternative Catalog Number:
USB-364895-200
Manufacturer:
US Biological
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, IHC, WB
Immunogen:
Recombinant protein corresponding to Gln24-Thr111 of human RETNLb, expressed in E. coli.
The 111aa FIZZ2 protein, which shows 59% sequence identity to mouse Fizz2 and 47% identity to human FIZZ3, shares an N-terminal signal peptide and a C-terminal stretch of 10 cysteine residues with identical spacing with other FIZZ family members. Strong expression of mouse Fizz2 mRNA was found in the adult colon in the mucosal crypt epithelial cells. Increases in circulating resistin or RELMB levels markedly stimulated hepatic glucose production despite the presence of fixed physiologic insulin levels. This enhanced rate of glucose output was due to increased flux through glucose-6-phosphatase. The results supported the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunocytochemistry: 1:50-500 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
