LGK974 is a highly potent inhibitor of Porcupine (PORCN), a Wnt-specific acyltransferase. LGK974 is orally bioavailable and inhibits WNT signaling in vitro and in vivo. It is reported to exhibit anti-tumor properties without increasing cytotoxicity Synonyms: 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide, LGK-974, WNT-974, LGK 974, NVP-LGK974, 2,3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4-bipyridine]-5-acetamide, 2-(2,3-Dimethyl-[2,4-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide CAS Number: 1243244-14-5 Molecular Formula: C23H20N6O Molecular Weight: 396.44 Purity (HPLC): 95% Appearance: Off-white to white solid Melting Point: 176-180C (lit) Solubility: Chloroform (Slightly), Methanol (Slightly) Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric analysis TLC Conditions: SiO2, Dichloromethane: Methanol=9:1, Visualized with UV and AMCS, Single Spot, Rf=0.40 Water Content (KF): As Reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
396.44
CAS Number:
[1243244-14-5]
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