CD38, also known as ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, is a surface molecule which has been attributed the function of a signaling channel leading to cellular activation and proliferation, an ectoenzyme with multiple function as well as an inducer of Ca2+ mobilization from cytoplasmic stores. It also functions as a plasma membrane signaling receptor in leukocytes. On B cells, It acts as a coreceptor and modulates B cell receptor (BCR) signals. Source: Recombinant protein corresponding to aa43-300 from human CD38, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~31.2kD (269aa) 28-40KD (SDS-PAGE under reducing conditions.) Amino Acid Sequence: ADPEFVPRWR QQWSGPGTTK RFPETVLARC VKYTEIHPEM RHVDCQSVWD AFKGAFISKH PCNITEEDYQ PLMKLGTQTV PCNKILLWSR IKDLAHQFTQ VQRDMFTLED TLLGYLADDL TWCGEFNTSK INYQSCPDWR KDCSNNPVSV FWKTVSRRFA EAACDVVHVM LNGSRSKIFD KNSTFGSVEV HNLQPEKVQT LEAWVIHGGR EDSRDLCQDP TIKELESIIS KRNIQFSCKN IYRPDKFLQC VKNPEDSSCT SEIHHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
