BRMS1, Recombinant, Human, aa1-235, GST-Tag (Breast Cancer Metastasis-suppressor 1)

Product Overview

• Article Name: BRMS1, Recombinant, Human, aa1-235, GST-Tag (Breast Cancer Metastasis-suppressor 1)
• Biozol Catalog Number: USB-372485
• Supplier Catalog Number: 372485
• Alternative Catalog Number: USB-372485-20,USB-372485-100,USB-372485-1
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at Lys-310. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. Source: Recombinant protein corresponding to aa1-235 from human BRMS1, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~54.3kD Amino Acid Sequence: MPVQPPSKDTEEMEAEGDSAAEMNGEEEESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQRSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLQGELQERIQRLEEDRQSLDLSSEWWDDKLHARGSSRSWDSLPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAA Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 54.3
• UniProt: Q9HCU9
• Purity: 90% (SDS-PAGE)
• Form: Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.