RAD23A, Recombinant, Human, aa1-363, His-Tag (UV Excision Repair Protein RAD23 Homolog A)

Product Overview

• Article Name: RAD23A, Recombinant, Human, aa1-363, His-Tag (UV Excision Repair Protein RAD23 Homolog A)
• Biozol Catalog Number: USB-374984
• Supplier Catalog Number: 374984
• Alternative Catalog Number: USB-374984-20,USB-374984-100
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to Lys-48-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to Lys-63-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to Lys-48-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to Lys-63-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome. Source: Recombinant protein corresponding to aa1-363 from human RAD23A, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~41.6kD Amino Acid Sequence: MAVTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGRDAFPVAGQKLIYAGKILSDDVPIRDYRIDEKNFVVVMVTKTKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAREDKSPSEESAPTTSPESVSGSVPSSGSSGREEDAASTLVTGSEYETMLTEIMSMGYERERVVAALRASYNNPHRAVEYLLTGIPGSPEPEHGSVQESQVSEQPATEAAGENPLEFLRDQPQFQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRHQEQFIQMLNEPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQNFDDE Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 41.6
• UniProt: P54725
• Purity: 85% (SDS-PAGE)
• Form: Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.