CD1A, also known as T-cell surface glycoprotein CD1a isoform 1, is the CD1 family of transmembrane glycoproteins. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. Also, it is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. Source: Recombinant protein corresponding to aa19-300 from human CD1A, fused to His-Tag at C- terminal, expressed in insect cell. Molecular Weight: ~33.2kD (291aa), 28-40kD (SDS-PAGE under reducing conditions.) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: ADPDGLKEPL SFHVTWIASF YNHSWKQNLV SGWLSDLQTH TWDSNSSTIV FLCPWSRGNF SNEEWKELET LFRIRTIRSF EGIRRYAHEL QFEYPFEIQV TGGCELHSGK VSGSFLQLAY QGSDFVSFQN NSWLPYPVAG NMAKHFCKVL NQNQHENDIT HNLLSDTCPR FILGLLDAGK AHLQRQVKPE AWLSHGPSPG PGHLQLVCHV SGFYPKPVWV MWMRGEQEQQ GTQRGDILPS ADGTWYLRAT LEVAAGEAAD LSCRVKHSSL EGQDIVLYWE HHSSVHHHHH H Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
