CEACAM3, also known as carcinoembryonic antigen-related cell adhesion molecule 3 isoform 1, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression. Also, it mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Recombinant protein corresponding to aa35-155 from human CEACAM3, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~14.2kD (130aa), 13.5-18kD (SDS-PAGE under reducing conditions.) Amino Acid Sequence: ADPKLTIESM PLSVAEGKEV LLLVHNLPQH LFGYSWYKGE RVDGNSLIVG YVIGTQQATP GAAYSGRETI YTNASLLIQN VTQNDIGFYT LQVIKSDLVN EEATGQFHVY QENAPGLPVG AVAGHHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
