CRLF2, Recombinant, Human, aa23-231, His-Tag (Cytokine Receptor-like Factor 2 Isoform 1, CRLF2, CRL2, CRLF2Y, TSLPR)

Product Overview

• Article Name: CRLF2, Recombinant, Human, aa23-231, His-Tag (Cytokine Receptor-like Factor 2 Isoform 1, CRLF2, CRL2, CRLF2Y, TSLPR)
• Biozol Catalog Number: USB-377772
• Supplier Catalog Number: 377772
• Alternative Catalog Number: USB-377772-50
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

CRLF2, also known as cytokine receptor-like factor 2 isoform 1, is a receptor for thymic stromal lymphopoietin. It is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed CRLF2 and the IL-7R alpha-chain. The protein induces phosphorylation of Stat3 and Stat5 also activate JAK2 pathways. CRLF2 and IL-7R alpha are principally coexpressed on monocytes and dendritic cell populations and to a much lesser extent of various lymphoid cells. Source: Recombinant protein corresponding to aa23-231 from human CRLF2, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~25.2kD (218aa), 28-40kD (SDS-PAGE under reducing conditions.) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: ADPQGGAAEG VQIQIIYFNL ETVQVTWNAS KYSRTNLTFH YRFNGDEAYD QCTNYLLQEG HTSGCLLDAE QRDDILYFSI RNGTHPVFTA SRWMVYYLKP SSPKHVRFSW HQDAVTVTCS DLSYGDLLYE VQYRSPFDTE WQSKQENTCN VTIEGLDAEK CYSFWVRVKA MEDVYGPDTY PSDWSEVTCW QRGEIRDACA ETPTPPKPKL SKHHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Properties

• Molecular Weight: 25.2
• NCBI: 071431
• UniProt: Q9HC73
• Purity: ~95% (SDS-PAGE)
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.