Ctsd, Recombinant, Mouse, aa21-410, His-Tag (Cathepsin D, CatD, CD)

Product Overview

• Article Name: Ctsd, Recombinant, Mouse, aa21-410, His-Tag (Cathepsin D, CatD, CD)
• Biozol Catalog Number: USB-377779
• Supplier Catalog Number: 377779
• Alternative Catalog Number: USB-377779-5,USB-377779-20
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

Ctsd, also known as cathepsin D, is peptidase belonging to the family of aspartic peptidases. It is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. It plays an important role in alpha-synuclein degradation, and neuronal survival. It has also been shown to mediate apoptosis induced by various stimuli and p53-dependent tumor suppression. Source: Recombinant protein corresponding to aa24-188 from mouse Ctsd, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~44.0kD (398aa), 40-57kD (SDS-PAGE under reducing conditions) Endotoxin: <1EU/1ug (determined by LAL method) Biological Activity: Specific activity is >1000pmol/min/ug in which one unit will convert 1pmole of Mca-PLGL-Dpa-AR-NH2 to MCA- Pro-Leu-OH/minute at pH 3.5 at 25C. Amino Acid Sequence: IIRIPLRKFT SIRRTMTEVG GSVEDLILKG PITKYSMQSS PKTTEPVSEL LKNYLDAQYY GDIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KILDIACWVH HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC KSDQSKARGI KVEKQIFGEA TKQPGIVFVA AKFDGILGMG YPHISVNNVL PVFDNLMQQK LVDKNIFSFY LNRDPEGQPG GELMLGGTDS KYYHGELSYL NVTRKAYWQV HMDQLEVGNE LTLCKGGCEA IVDTGTSLLV GPVEEVKELQ KAIGAVPLIQ GEYMIPCEKV SSLPTVYLKL GGKNYELHPD KYILKVSQGG KTICLSGFMG MDIPPPSGPL WILGDVFIGS YYTVFDRDNN RVGFANAVVL LEHHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 44
• NCBI: 034113
• UniProt: P18242
• Purity: 90% (SDS-PAGE)
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.