CTSL, Recombinant, Human, aa18-333, His-Tag (Cathepsin L1, Cathepsin L1 Isoform 1, CATL, CTSL1, MEP)
Catalog Number:
USB-377780
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| Article Name: | CTSL, Recombinant, Human, aa18-333, His-Tag (Cathepsin L1, Cathepsin L1 Isoform 1, CATL, CTSL1, MEP) |
| Biozol Catalog Number: | USB-377780 |
| Supplier Catalog Number: | 377780 |
| Alternative Catalog Number: | USB-377780-50 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| CTSL, also known as cathepsin L1 isoform 1, is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. Recombinant protein corresponding to aa18-333 from human CTSL, fused to His-Tag, expressed in E. coli. Molecular Weight: ~38.3kD (339aa), confirmed by MALDI-TOF Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSTLTFDHS LEAQWTKWKA MHNRLYGMNE EGWRRAVWEK NMKMIELHNQ EYREGKHSFT MAMNAFGDMT SEEFRQVMNG FQNRKPRKGK VFQEPLFYEA PRSVDWREKG YVTPVKNQGQ CGSCWAFSAT GALEGQMFRK TGRLISLSEQ NLVDCSGPQG NEGCNGGLMD YAFQYVQDNG GLDSEESYPY EATEESCKYN PKYSVANDTG FVDIPKQEKA LMKAVATVGP ISVAIDAGHE SFLFYKEGIY FEPDCSSEDM DHGVLVVGYG FESTESDNNK YWLVKNSWGE EWGMGGYVKM AKDRRNHCGI ASAASYPTV Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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