DKK3, Recombinant, Human, aa22-350, His-Tag (Dickkopf-related Protein 3, Dickkopf WNT Signaling Pathway Inhibitor 3, RIG, REIC)

Product Overview

• Article Name: DKK3, Recombinant, Human, aa22-350, His-Tag (Dickkopf-related Protein 3, Dickkopf WNT Signaling Pathway Inhibitor 3, RIG, REIC)
• Biozol Catalog Number: USB-377787
• Supplier Catalog Number: 377787
• Alternative Catalog Number: USB-377787-20
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

DKK3, also known as dickkopf WNT signaling pathway inhibitor 3, is a member of the DKK protein family including Dkk-1, 2, 3 and 4. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Source: Recombinant protein corresponding to aa22-350 from human DKK3 protein, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~37.3kD (338aa), 40-57kD (SDS-PAGE under reducing conditions.) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: ADPAPAPTAT SAPVKPGPAL SYPQEEATLN EMFREVEELM EDTQHKLRSA VEEMEAEEAA AKASSEVNLA NLPPSYHNET NTDTKVGNNT IHVHREIHKI TNNQTGQMVF SETVITSVGD EEGRRSHECI IDEDCGPSMY CQFASFQYTC QPCRGQRMLC TRDSECCGDQ LCVWGHCTKM ATRGSNGTIC DNQRDCQPGL CCAFQRGLLF PVCTPLPVEG ELCHDPASRL LDLITWELEP DGALDRCPCA SGLLCQPHSH SLVYVCKPTF VGSRDQDGEI LLPREVPDEY EVGSFMEEVR QELEDLERSL TEEMALREPA AAAAALLGGE EIHHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Properties

• Molecular Weight: 37.3
• NCBI: 001018067
• UniProt: Q9UBP4
• Purity: ~90% (SDS-PAGE)
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.