KLRK1, Recombinant, Human, aa73-216, hIgG-His-Tag (Killer Cell Lectin-like Receptor Subfamily K Member 1, CD314, KLR, NKG2-D, NKG2D)
Biozol Catalog Number:
USB-377881
Supplier Catalog Number:
377881
Alternative Catalog Number:
USB-377881-50
Manufacturer:
US Biological
Category:
Molekularbiologie
KLRK1, also known as NKG2D ligand 4 isoform 1, is a type ll transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. It can send co-stimulatory signals to activate CD8 T cells. Also, it plays an important role in viral control. Cellular stress can induce ligands for KLRK1 which results in the cell susceptible to NK cell-mediated lysis. Source: Recombinant protein corresponding to aa73-216 from human KLRK1, fused to hIgG-His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~43.9kD (386aa) 40-57kD (SDS-PAGE under reducing conditions.) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: ADPIWSAVFL NSLFNQEVQI PLTESYCGPC PKNWICYKNN CYQFFDESKN WYESQASCMS QNASLLKVYS KEDQDLLKLV KSYHWMGLVH IPTNGSWQWE DGSILSPNLL TIIEMQKGDC ALYASSFKGY IENCSTPNTY ICMQRTVVEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
