CD164, also known as sialomucin core protein 24 isoform 1, is a type I transmembrane O-glycosylated protein that is expressed on activated perivascular and stromal cells in embryonic and tumor neovasculature. It plays a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. This protein also plays an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Recombinant human CD164, fused to His-Tag at C-terminal, expressed in insect cell and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa24-162 of human CD164, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~15.6kD (148aa), ~28-57kD (SDS-PAGE under reducing conditions.) Endotoxin: <1EU/1ug (determined by LAL method) AA Sequence: ADPDKNTTQH PNVTTLAPIS NVTSAPVTSL PLVTTPAPET CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC QVGNTTDFCS VSTATPVPTA NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT PTSQPVRKST FDHHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
