FCER2, Recombinant, Human, aa48-321, His-Tag (Low Affinity Immunoglobulin Epsilon Fc Receptor Isoform A, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF)

Product Overview

• Article Name: FCER2, Recombinant, Human, aa48-321, His-Tag (Low Affinity Immunoglobulin Epsilon Fc Receptor Isoform A, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF)
• Biozol Catalog Number: USB-396865
• Supplier Catalog Number: 396865
• Alternative Catalog Number: USB-396865-10,USB-396865-50,USB-396865-100,USB-396865-250
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

FCER2, also known as low affinity immunoglobulin epsilon Fc receptor isoform a, is a member of subgroup II of the C-type (Ca++-dependent) lectin superfamily. It is a low affinity receptor for B cell specific antigen and IgE. It plays an essential role in the growth and differentiation of B cells, and in the regulation of IgE production. This protein also exists in a soluble secretion form and functions as a powerful cleavage-promoting growth factor. Increased levels of soluble CD23 / FCER2 lead to the recruitment of unaffected B cells in the presentation of antigen peptides to allergen-specific B cells. Recombinant human FCER2, fused to His-Tag at C-terminal, expressed in insect cell and purified by using conventional chromatography techniques. Recombinant protein corresponding to aa48-321 of human FCER2, fused to His-Tag at C-terminal, expressed in Baculovirus (insect cell). Swiss/Uniprot Accession: P06734 Molecular Weight: ~32kD (283aa) Biological Activity: The ED50 range is 15ug/ml as measured by its binding ability in a functional ELISA with human IgE. Amino Acid Sequence: DTTQSLK QLEERAARNV SQVSKNLESH HGDQMAQKSQ STQISQELEE LRAEQQRLKS QDLELSWNLN GLQADLSSFK SQELNERNEA SDLLERLREE VTKLRMELQV SSGFVCNTCP EKWINFQRKC YYFGKGTKQW VHARYACDDM EGQLVSIHSP EEQDFLTKHA SHTGSWIGLR NLDLKGEFIW VDGSHVDYSN WAPGEPTSRS QGEDCVMMRG SGRWNDAFCD RKLGAWVCDR LATCTPPASE GSAESMGPDS RPDPDGRLPT PSAPLHS Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 32
• NCBI: 001993
• UniProt: P06734
• Purity: 90% (SDS-PAGE). Endotoxin: 1EU/ug (LAL).
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.