(2R)-2-Deoxy-3-O-[(1,1-dimethylethyl)dimethylsilyl]-2-fluoro-2-methyl-uridine, CAS [[1244762-86-4]]

Product Overview

• Article Name: (2R)-2-Deoxy-3-O-[(1,1-dimethylethyl)dimethylsilyl]-2-fluoro-2-methyl-uridine, CAS [[1244762-86-4]]
• Biozol Catalog Number: USB-421285
• Supplier Catalog Number: 421285
• Alternative Catalog Number: USB-421285-5,USB-421285-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

(2R)-2-Deoxy-3-O-[(1,1-dimethylethyl)dimethylsilyl]-2-fluoro-2-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2-deoxy-2-alpha-fluoro-beta-C-methyluridine-5-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Molecular Formula: C16H27FN2O5Si Solubility: DMSO (Slightly), Methanol (Slightly) Molecular Weight: 374.48 Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 374.48
• Form: Supplied as a White Solid
• CAS Number: [1244762-86-4]