(2R)-2-Deoxy-3,5-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2-fluoro-2-methyl-uridine, CAS [[1393526-40-3]]

Product Overview

• Article Name: (2R)-2-Deoxy-3,5-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2-fluoro-2-methyl-uridine, CAS [[1393526-40-3]]
• Biozol Catalog Number: USB-421286
• Supplier Catalog Number: 421286
• Alternative Catalog Number: USB-421286-10,USB-421286-25
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

(2R)-2-Deoxy-3,5-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2-fluoro-2-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2-deoxy-2-alpha-fluoro-beta-C-methyluridine-5-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Molecular Formula: C22H41FN2O5Si2 Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol Molecular Weight: 488.74 Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 488.74
• Form: Supplied as a Pale Yellow Oil
• CAS Number: [1393526-40-3]