Azoxymethane is a nonsteroidal anti-inflammatory drug that has been used to induce colitis in animals. It binds to the toll-like receptor 4 (TLR4) and TLR2, which are proteins on the cell surface that are involved in the inflammatory response. Azoxymethane also inhibits dioxin production by altering the activity of photosynthetic bacteria. Dioxins are toxic byproducts of combustion processes and can cause cancer in humans. Azoxymethane has been shown to be effective in animal models for colon cancer, squamous cell carcinoma, and other cancers. It may also be useful for preventing or treating bowel diseases such as Crohns disease and ulcerative colitis. Synonyms: AOM, Dimethyldiazene 1-oxide, ONN-Azoxydimethane, 1,2-Dimethyldiazene 1-oxide CAS No: 25843-45-2 Molecular Formula: C2H6N2O Molecular Weight: 74.08 Appearance: Oil Purity: 98% Boiling Point: 97-99C (lit.) Density: 0.991g/ml at 25C (lit.) Storage and Stability: Store lyophilized at -20C, keep desiccated. In lyophilized form, the chemical is stable for 24 months. In solution, store at -20C and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Molecular Weight:
74.08
Purity:
98%
Form:
Oil
CAS Number:
[25843-45-2]
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