Bithionol is an anthelmintic drug. Formulations containing bithionol have demonstrated efficacy against cestodes and trematodes, as well as other parasitic worms.1,2,3 Bithionol inhibits host caspases, including caspases-1, -3, -6, -7, and -9, which act as hub proteins that mediate the lethality of multiple pathogenic agents.4 By blocking host caspases, bithionol reduces the detrimental effects of anthrax lethal toxin, diphtheria toxin, cholera toxin, P. aeruginosa exotoxin A, Botulinum neurotoxin, ricin, and Zika virus.4 Bithionol also inhibits NF-kappaB activation by blocking phosphorylation of IkappaBalpha (IC50 = 15.8uM in a reporter gene assay).5 Synonyms: 2,2-thiobis[4,6-dichloro-phenol], Bis(3,5-dichloro-2-hydroxyphenyl) Sulfide CAS No: 97-18-7 Molecular Formula: C12H6Cl4O2S Molecular Weight: 356.05 Appearance: 356.05 Purity 97% (GC) Melting Point: 184-188C Solubility: Methanol Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
356.05
Purity:
97% (GC)
CAS Number:
[97-18-7]
* VAT and and shipping costs not included. Errors and price changes excepted
