C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO (AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients. Molecular Formula: C24H19N3O6 Solubility: DMSO (Slightly), Methanol (Slightly, Heated) Molecular Weight: 445.42 Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
445.42
Form:
Supplied as a Dark Orange Solid
CAS Number:
[328968-36-1]
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