CY 208-243 is a centrally active dopamine D1 receptor agonist, selective over D2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125nM. Unlike SKF 38393, it exerts antiParkinsonian activity in animal models. Synonyms: (6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-ab]phenanthridine, (6aR-trans)-4,6,6a,7,8,12b-Hexahydro-7-methyl-indolo[4,3-ab]phenanthridine CAS No: 100999-26-6 Molecular Formula: C19H18N2 Molecular Weight: 274.36 Appearance: White solid Purity (TLC): Rf = 0.62 (Pyridine:Acetic acid:Water:Butanol [3:8:11:33]) H NMR: Conforms to reference Melting Point: 227-228C Solubility: DMSO: 100mM Storage and Stability: May be stored at RT.
