Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).1 Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself. Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth. It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet. Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13mg/Kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage. Cytosporone B also has antibacterial properties. Synonyms: Dothiorelone G, 3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic Acid Ethyl Ester, Csn-B CAS No: 321661-62-5 Molecular Formula: C18H26O5 Molecular Weight: 322.40 Purity: 98% Appearance: Supplied as a cystalline solid Solubility: Soluble in ethanol and DMSO at ~30mg/ml and DMF at ~50mg/ml purged with inert gas Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 6 months after receipt at -20C. Reconstitute with solvent. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
322.4
Purity:
98%
Form:
Supplied as a cystalline solid
CAS Number:
[321661-62-5]
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