Dolutegravir O-beta-D-Glucuronide Methyl Ester is an intermediate in synthesizing Dolutegravir O-beta-D-Glucuronide (D528810), a metabolite of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Molecular Formula: C27H29F2N3O11 Solubility: Dichloromethane, Methanol Molecular Weight: 609.53 Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
609.53
Form:
Supplied as a Off White Solid
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