G-1 is a potent and selective G protein-coupled estrogen receptor (GPER) agonist (Ki = 11 nM, EC50 = 2 nM), displays no activity at ERalpha and ERbeta at concentrations up to 10 µM. Increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants (IC50 values are 0.7 and 1.6 nM respectively) in vitro. Blocks MCF-1 cell cycle progression at the G1 phase. Displays therapeutic effects in the mouse EAE model of multiple sclerosis. Molecular Formula: C21H18BrNO3 Solubility: DMSO (Slightly), Methanol (Slightly, Heated) Molecular Weight: 412.28 Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
412.28
Form:
Supplied as a Off-White Solid
CAS Number:
[881639-98-1]
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