| Norepinephrine is a hormone and neurotransmitter that is released by the adrenal medulla. It has vasoconstrictor and bronchodilator effects, as well as other actions such as increasing metabolic rate and blood pressure. Norepinephrine binds to beta-adrenergic receptors on cells, causing them to release cyclic adenosine monophosphate (cAMP) in response. cAMP activates protein kinase A, which phosphorylates proteins leading to increased cell activity. The binding of norepinephrine to beta-adrenergic receptors also leads to the activation of voltage-dependent calcium channels and increased calcium ion permeability. This increase in intracellular calcium ions leads to muscle contraction and relaxation of smooth muscle in the lungs, uterus, stomach, intestines and bladder. Norepinephrine can be used in a luminescence immunoassay for the measurement of noradrenaline levels in human serum or plasma samples. Synonyms: (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, l-Arterenol, (-)- alpha-(Aminomethyl)-3,4-dihydroxy-benzyl Alcohol, 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol, (-)-Arterenol, (-)-Noradrenaline, (-)-Norepinephrine, (-)-alpha-(Aminomethyl)protocatechuyl Alcohol, (R)-(-)-Norepinephrine, (R)-Noradrenaline, (R)-Norepinephrine, Adrenor, Aktamin, Arterenol, Levarterenol, Levoarterenol, Levonor, Levonoradrenaline, Levonorepinephrine, Levophed, Nor-Epirenan, Noradrenalin, Noradrenaline, Norartrinal, Norepinephrine, Norepirenamine, Sympathin E, l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol, l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol, l-3,4-Dihydroxyphenylethanolamine, l-Arterenol, l-Noradrenaline, l-Norepinephrine, l-alpha-(Aminomethyl)-3,4-dihydroxybenzyl Alcohol CAS No: 51-41-2 Molecular Formula: C8H11NO3 Molecular Weight: 169.18 Appearance: White to off-white solid Purity: 99% Melting Point: >205C (dec.) Solubility: Aqueous Acid (Slightly), DMSO (Slightly) Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
