LUF 5834 is a novel adenosine A1 receptor agonist that has been shown to have significant efficacy in vivo against inflammatory diseases. It was found to be a potent and selective agonist of the A1 receptor in vitro. LUF 5834 also had an allosteric modulating effect on the adenosine A3 receptor, which is involved in immune and inflammatory responses. LUF 5834 binds to both the adenosine A1 receptor and the A3 receptor with high affinity and selectivity, but does not bind to any other adenosine receptors at concentrations up to 10 µM. The binding site for LUF 5834 on the A1 receptor was determined by molecular modeling studies as well as binding experiments. These results suggest that LUF 5834 can be used for treating inflammatory diseases or other disorders involving inflammation. Synonyms: 2-Amino-4-(4-hydroxyphenyl)- 6-(1H-imidazol-2-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile CAS No: 333962-91-7 Molecular Formula: C17H12N6OS Molecular Weight: 348.38 Appearance: White to off-white powder Purity: 98% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
348.38
Purity:
98%
Form:
White to off-white powder
CAS Number:
[333962-91-7]
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