| Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport.1 Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36uM. Synonyms: (1S,2R,4E,5S,6S,6S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-22-Ethyl-3,4,5,6-tetrahydro-7,11,14,15-tetrahydroxy-6-[(2R)-2-hydroxypropyl]-5,6,8,10,12,14,16,29-octamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2-[2H]pyran]-3,9,13-trione, Spiro[2,26-dioxabicyclo[23.3.1]nonacosane-27,2-[2H]pyran], oligomycin A deriv., A 272, Oligomycin D, RR 32705, Rutamycin A CAS No: 1404-59-7 Molecular Formula: C44H72O11 Molecular Weight: 777.04 Appearance: White to off-white powder Purity: 95% Solubility: DMF, DMSO, Ethanol, Methanol Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
