Pyridostatin stabilizes G-quadruplexes (G4s) in cells and elicits a DNA damage response by causing the formation of DNA double strand breaks (DSB). Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets gene bodies containing clusters of sequences with a propensity for G-quadruplex formation. As a result, pyridostatin modulated the expression of these genes, including the proto-oncogene SRC. Synonyms: 4-(2-aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide tris(2,2,2-trifluoroacetate), Pyridostatin TFA Salt CAS No: 1472611-44-1 Free Base: 1085412-37-8 Molecular Formula: C37H35F9N8O11 Molecular Weight: 938.72 Purity: 95% Appearance: White to off-white solid Solubility: Soluble in DMSO, not soluble in water Storage and Stability: Store at -20C. Stable for 6 months after receipt.
Molecular Weight:
938.72
CAS Number:
[1472611-44-1]
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