Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein. Synonyms: 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-,(1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl ester, (2S)-2-Piperidinecarboxylic Acid Molecular Formula: C42H56N2O10 Molecular Weight: 748.9 Appearance: White to off-white solid Purity: 99% Solubility: Chloroform (Slightly), Methanol (Slightly) Method for Determining Ientity: Proton NMR Spectroscopic and Mass Spectrometric analysis TLC Conditions: SiO2, Dichloromethane:Methanol=9:1, Visualized with UV and KMnO4, Single Spot, Rf=0.75 Elemental Analysis: Calculated: %C: 67.36, %H: 7.54, %N: 3.74 Specific Rotation (c=0.2, Methanol): As Reported Storage and Stability: Store at 4C. Hygroscopic, Store under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
748.9
Purity:
99%
Form:
White to off-white solid
CAS Number:
[914805-33-7]
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