VU 6005649 is a positive allosteric modulator of mGlu7 and mGlu8 receptors (EC50 = 0.65uM and 2.6uM for mGlu7 and mGlu8, respectively). Displays >3.8 fold selectivity for mGlu7 and mGlu8 over other mGlu receptors (EC50 >10uM for mGlu1,2,3,4,5,6). Also NK1 receptor antagonist (Ki= 650 nM, IC50 = 3.4uM). Brain penetrant. Synonyms: 3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine CAS No: 2137047-43-7 Molecular Formula: C16H12F5N3O Molecular Weight: 357.28 Solubility: 100mM in DMSO and to 50mM in ethanol Purity: 98% Appearance: Yellow solid 1H NMR and MS: Consistent with structure Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
357.28
Purity:
98%
Form:
Yellow solid
CAS Number:
[2137047-43-7]
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