CHFR (E3 Ubiquitin-Protein Ligase CHFR, Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase), Rabbit
Catalog Number:
USB-477928
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| Article Name: | CHFR (E3 Ubiquitin-Protein Ligase CHFR, Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase), Rabbit |
| Biozol Catalog Number: | USB-477928 |
| Supplier Catalog Number: | 477928 |
| Alternative Catalog Number: | USB-477928-100 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IHC, WB |
| Immunogen: | Synthetic peptide corresponding to the N-terminal region of human CHFR |
| CHFR is an E3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when they are exposed to microtubule poisons. It acts in early prophase before chromosome condensation, when the centrosome moves apart from each other along the periphery of the nucleus. CHFR probably promotes the formation of Lys-63-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at Lys-63 are usually not targeted for degradation, but are rather involved in signaling cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress caused by microtubule poisons. Applications: Suitable for use in Immunohistochemistry, Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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