HLA-DPA1 (HLA Class II Histocompatibility Antigen, DP Alpha 1 Chain, Major Histocompatibility Complex, Class II, DP Alpha 1), Rabbit
Catalog Number:
USB-482778
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| Article Name: | HLA-DPA1 (HLA Class II Histocompatibility Antigen, DP Alpha 1 Chain, Major Histocompatibility Complex, Class II, DP Alpha 1), Rabbit |
| Biozol Catalog Number: | USB-482778 |
| Supplier Catalog Number: | 482778 |
| Alternative Catalog Number: | USB-482778-100 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Immunogen: | Synthetic peptide corresponding to the middle region of human HLA-DPA1 |
| The specific function of this protein remains unknown.HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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