BTLA, Recombinant, Mouse, aa30-176, hIgG-His-Tag

Product Overview

• Article Name: BTLA, Recombinant, Mouse, aa30-176, hIgG-His-Tag
• Biozol Catalog Number: USB-497019
• Supplier Catalog Number: 497019
• Alternative Catalog Number: USB-497019-10,USB-497019-20
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

BTLA, also known as B- and T-lymphocyte attenuator isoform 1, is an inhibitory molecule which belongs to the Ig superfamily. It is a type 1 transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. This protein is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1). Unlike other CD28 family members, the BTLA Ig domain in the ECD is of the I-type rather than V-type, and BTLA does not form homodimers. It is also unusual in its interaction with the TNF superfamily member HVEM rather than with B7 family ligands. And, it is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses. Recombinant protein corresponding to aa30-176 from mouse BTLA, fused to hIgG-His-Tag at C-terminal, expressed in HEK293 cells. Molecular Weight: ~44.1kD Amino Acid Sequence: EKATKR NDEECEVQLN IKRNSKHSAW TGELFKIECP VKYCVHRPNV TWCKHNGTIW PLEVGPQLY TSWEENRSVP VFVLHFKPIH LSDNGSYSCS TNFNSQVINS HSVTIHVRER TQNSSEHPLI ISDIPDATNA SGPSTMEKRP G Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 44.139
• NCBI: 08964
• UniProt: Q32MV9
• Purity: 95% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL).
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol