C-Reactive Protein, Recombinant, Human, aa19-224, His-Tag

Product Overview

• Article Name: C-Reactive Protein, Recombinant, Human, aa19-224, His-Tag
• Biozol Catalog Number: USB-497020
• Supplier Catalog Number: 497020
• Alternative Catalog Number: USB-497020-10,USB-497020-20
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

CRP, also known as C-reactive protein, is a member of the pentaxin family. This protein is found in the blood, its levels rise dramatically during inflammatory processes occurring in the body. This increment is due to a rise in the plasma concentration of IL-6, which is produced predominantly by macrophages as well as adipocytes. Its physiological role is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via C1q. It is also play another important role in innate immunity, as an early defense system against infections. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases. Recombinant protein corresponding to aa19-224 from human C-Reactive Protein, fused to His-Tag at C-terminal, expressed in HEK293 cells. Molecular Weight: ~24.1kD AA Sequenc:e: QTDMSRK AFVFPKESDT SYVSLKAPLT KPLKAFTVCL HFYTELSSTR GYSIFSYATK RQDNEILIFW SKDIGYSFTV GGSEILFEVP EVTVAPVHIC TSWESASGIV EFWVDGKPRV RKSLKKGYTV GAEASIILGQ EQDSFGGNFE GSQSLVGDIG NVNMWDFVLS PDEINTIYLG GPFSPNVLNW RALKYEVQGE VFTKPQLWP Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 24.1215
• NCBI: 000558
• UniProt: P02741
• Purity: 90% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL)
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol