CD6, Recombinant, Human, aa18-402, hIgG-His-Tag

Article Name:	CD6, Recombinant, Human, aa18-402, hIgG-His-Tag
Biozol Catalog Number:	USB-497028
Supplier Catalog Number:	497028
Alternative Catalog Number:	USB-497028-10,USB-497028-20,USB-497028-100,USB-497028-250,USB-497028-500
Manufacturer:	US Biological
Category:	Molekularbiologie

CD6, also known as T-cell differentiation antigen CD6, is a member of the group B SRCR (scavenger receptor cysteine-rich) superfamily. CD6 is a cell surface glycoprotein expressed primarily on T cells and It expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. And T-cell differentiation antigen CD6 appears to play a role as both a co-stimulatory molecule in T cell activation and as an adhesion receptor. CD6 binds to CD166(known as ALCAM), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development.. Certain alleles of this protein may be associated with susceptibility to multiple sclerosis. Recombinant protein corresponding to aa18-402 from human CD6, fused to hIgG-His-Tag at C-terminal, expressed in Baculovirus. Molecular Weight: ~68.3kD Biological Activity: Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. When cells are added to human CD6 coated plates 10ug/ml. This effect is more to 50%. Amino Acid Sequence: ALGCGGAEAA SQLAPPTPEL PPPPAAGNTS VAANATLAGA PALLCSGAEW RLCEVVEHAC RSDGRRARVT CAENRALRLV DGGGACAGRV EMLEHGEWGS VCDDTWDLED AHVVCRQLGC GWAVQALPGL HFTPGRGPIH RDQVNCSGAE AYLWDCPGLP GQHYCGHKED AGAVCSEHQS WRLTGGADRC EGQVEVHFRG VWNTVCDSEW YPSEAKVLCQ SLGCGTAVER PKGLPHSLSG RMYYSCNGEE LTLSNCSWRF NNSNLCSQSL AARVLCSASR SLHNLSTPEV PASVQTVTIE SSVTVKIENK ESRELMLL Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:	68.3627
NCBI:	006716
UniProt:	P30203
Purity:	90% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL).
Form:	Supplied as a liquid in PBS, pH 7.4, 10% glycerol