FOLR2, Recombinant, Human, aa22-230, His-Tag

Product Overview

• Article Name: FOLR2, Recombinant, Human, aa22-230, His-Tag
• Biozol Catalog Number: USB-497039
• Supplier Catalog Number: 497039
• Alternative Catalog Number: USB-497039-10,USB-497039-20
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

FOLR2, also known as Folate receptor beta, is a member of the folate receptor (FLOR) family. Members of this gene family have a high affinity for folate and folic acid analogs at neutral pH. And they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. It was originally thought to exist only in placenta, but is also expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. FOLR2 is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. Recombinant protein corresponding to aa22-230 from FOLR2, fused to His-Tag at C-terminal, expressed in HEK293 cells. Molecular Weight: ~25.1kD Biological Activity: Measured by its binding ability in a functional ELISA with Folic Acid-BSA. The ED50 range 5ug/ml. Amino Acid Sequence: QDRTDLLNVC MDAKHHKTKP GPEDKLHDQC SPWKKNACCT ASTSQELHKD TSRLYNFNWD HCGKMEPACK RHFIQDTCLY ECSPNLGPWI QQVNQSWRKE RFLDVPLCKE DCQRWWEDCH TSHTCKSNWH RGWDWTSGVN KCPAGALCRT FESYFPTPAA LCEGLWSHSY KVSNYSRGSG RCIQMWFDSA QGNPNEEVAR FYAAAMHVN Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 25.1215
• NCBI: 000794
• UniProt: P14207
• Purity: 90% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL)
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol