NCAM-1, Recombinant, Human, aa20-603, His-Tag

Product Overview

• Article Name: NCAM-1, Recombinant, Human, aa20-603, His-Tag
• Biozol Catalog Number: USB-497065
• Supplier Catalog Number: 497065
• Alternative Catalog Number: USB-497065-10,USB-497065-20
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

NCAM-1, also known as CD56, is a member of the immunoglobulin superfamily. It specifically binds to neuron neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. The polysialyation of NCAM-1 reduces its adhesive property and increases its neurite outgrowth promoting features. It has also been shown to be involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. This protein is preferentially expressed in NK cells and a subset of T lymphocytes that mediate MHC-unrestricted cell-mediated cytotoxicity. High expression of NCAM-1/CD56 differentiates NK cells as having an activated phenotype. CD56(+high) NK cells mediate heightened effector functions in response to IL-12. During hematopoiesis, NCAM-1/CD56 is the prototypic marker of NK cells, also present on subset of CD4+ T cells and CD8+ T cells. In cell adhesion, it contributes to cell-cell adhesion or cell-matrix adhesion during embryonic development. In anatomic pathology, pathologists make use of it immunohistochemistry to recognize certain tumors. Recombinant protein corresponding to aa20-603 from human NCAM-1, fused to His-Tag at C-terminal, expressed in Baculovirus. Molecular Weight: ~65.7kD Amino Acid Sequence: LQVDIVP SQGEISVGES KFFLCQVAGD AKDKDISWFS PNGEKLTPNQ QRISVVWNDD SSSTLTIYNA NIDDAGIYKC VVTGEDGSES EATVNVKIFQ KLMFKNAPTP QEFREGEDAV IVCDVVSSLP PTIIWKHKGR DVILKKDVRF IVLSNNYLQI RGIKKTDEGT YRCEGRILAR GEINFKDIQV IVNVPPTIQA RQNIVNATAN LGQSVTLVCD AEGFPEPTMS WTKDGEQIEQ EEDDEKYIFS DDSSQLTIKK VDKNDEAEYI CIAENKAGEQ DATIHLKVFA KPKITYVENQ TAMELEEQVT LTCEASGDPI PSITWRTSTR NISSEEKTLD GHMVVRSHAR VSSLTLKSIQ YTDAGEYICT ASNTIGQDSQ SMYLEVQYAP KLQGPVAVYT WEGNQVNITC EVFAYPSATI SWFRDGQLLP SSNYSNIKIY NTPSASYLEV TPDSENDFGN YNCTAVNRIG QESLEFILVQ ADTPSSPSID QVEPYSSTAQ VQFDEPEATG GVPILKYKAE WRAVGEEVWH SKWYDAKEAS MEGIVTIVGL KPETTYAVRL AALNGKGLGE ISAASEFKTQ PVHSPPP Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 65.7593
• NCBI: 001070150
• UniProt: P13591
• Purity: 95% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL)
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.