SARS-CoV Spike RBD, Recombinant, aa306-515, His-Tag
Catalog Number:
USB-497072
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| Article Name: | SARS-CoV Spike RBD, Recombinant, aa306-515, His-Tag |
| Biozol Catalog Number: | USB-497072 |
| Supplier Catalog Number: | 497072 |
| Alternative Catalog Number: | USB-497072-10,USB-497072-20 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| Alternative Names: | sars-cov |
| Severe acute respiratory syndrome coronavirus (SARS-CoV), middle eastern respiratory syndrome coronavirus (MERS-CoV), and the recently identified novel coronavirus (SARS-CoV-2) belong to the coronaviridae family, genus Betacoronavirus, that has been related to important epidemiological outbreaks. SARS-CoV emerged in 2003 as a significant threat to human health. SARS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein, responsible for allowing the virus to attach to and fuse with the membrane of a host cell and is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. It attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. A metallopeptidase, angiotensin-converting enzyme 2 (ACE-2), has been identified as a functional receptor for SARS-CoV through interaction with a receptor binding domain (RBD) located at the C-terminal of S1 subunit. Recombinant protein corresponding to aa306-515 from SARS-CoV Spike RBD, fused to His-Tag at C-terminal, expressed in Baculovirus. Molecular Weight: ~24.7kD Biological Activity: Measured by its binding ability in a functional ELISA with Human ACE-2. Amino Acid Sequrnce: |
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