CNTFR, Recombinant, Human, aa23-342, His-Tag (Ciliary Neurotrophic Factor Receptor Subunit alpha, CNTFR-alpha, Ciliary Neurotrophic Factor Receptor)

Product Overview

• Article Name: CNTFR, Recombinant, Human, aa23-342, His-Tag (Ciliary Neurotrophic Factor Receptor Subunit alpha, CNTFR-alpha, Ciliary Neurotrophic Factor Receptor)
• Biozol Catalog Number: USB-506167
• Supplier Catalog Number: 506167
• Alternative Catalog Number: USB-506167-50,USB-506167-250
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

CNTFR, also known as ciliary neurotrophic factor receptor subunit alpha preproprotein, is expressed in glial cells within the central and peripheral nervous systems. It stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types such as sensory, sympathetic, ciliary and motor neurons. This protein has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6. Also, it possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage. It activates downstream signaling molecules such as STAT-3 in areas of the hypothalamus which regulate food intake. Description: Recombinant protein corresponding to aa23-342 of human CNTFR, fused to His-tag at C-terminus, expressed in Baculovirus Molecular Weight: ~36.9kD (329aa), ~40-57kD (SDS-PAGE under reducing conditions) Endotoxin: <1EU/1ug (LAL) AA Sequence: ADPQRHSPQE APHVQYERLG SDVTLPCGTA NWDAAVTWRV NGTDLAPDLL NGSQLVLHGL ELGHSGLYAC FHRDSWHLRH QVLLHVGLPP REPVLSCRSN TYPKGFYCSW HLPTPTYIPN TFNVTVLHGS KIMVCEKDPA LKNRCHIRYM HLFSTIKYKV SISVSNALGH NATAITFDEF TIVKPDPPEN VVARPVPSNP RRLEVTWQTP STWPDPESFP LKFFLRYRPL ILDQWQHVEL SDGTAHTITD AYAGKEYIIQ VAAKDNEIGT WSDWSVAAHA TPWTEEPRHL TTEAQAAETT TSTTSSLAPP PTTKICDPGE LGSHHHHHH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 36.93294057
• NCBI: 001833
• UniProt: P26992
• Purity: >95% (SDS-PAGE)
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.