IL6R, Recombinant, Human, aa20-365, His-Tag (Interleukin-6 Receptor Subunit alpha Isoform 1, IL6R, CD126, gp80, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ)

Product Overview

• Article Name: IL6R, Recombinant, Human, aa20-365, His-Tag (Interleukin-6 Receptor Subunit alpha Isoform 1, IL6R, CD126, gp80, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ)
• Biozol Catalog Number: USB-506184
• Supplier Catalog Number: 506184
• Alternative Catalog Number: USB-506184-50,USB-506184-100
• Manufacturer: US Biological
• Category: Molekularbiologie

Product Description

IL6R, also known as interleukin-6 receptor subunit alpha isoform 1, is a type I cytokine receptor. It is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. It has a modular build of several immunoglobulin-like and fibronectin type III-like domains. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. It is implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Recombinant protein corresponding to aa20-365 of human IL6R, fused to His-tag at C-terminus, expressed in Baculovirus. Molecular Weight: ~39.6kD (355aa), ~40-57kD (SDS-PAGE under reducing conditions) Amino Acid Sequence: ADPLAPRRCP AQEVARGVLT SLPGDSVTLT CPGVEPEDNA TVHWVLRKPA AGSHPSRWAG MGRRLLLRSV QLHDSGNYSC YRAGRPAGTV HLLVDVPPEE PQLSCFRKSP LSNVVCEWGP RSTPSLTTKA VLLVRKFQNS PAEDFQEPCQ YSQESQKFSC QLAVPEGDSS FYIVSMCVAS SVGSKFSKTQ TFQGCGILQP DPPANITVTA VARNPRWLSV TWQDPHSWNS SFYRLRFELR YRAERSKTFT TWMVKDLQHH CVIHDAWSGL RHVVQLRAQE EFGQGEWSEW SPEAMGTPWT ESRSPPAENE VSTPMQALTT NKDDDNILFR DSANATSLPV QDSSSVPLPH HHHHH Biological Activity: Measured by its ability to inhibit proliferation using M1 mouse myeloid leukemia cells. The ED50 range <20ng/ml with Human IL-6. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 39.6
• NCBI: 000556
• UniProt: P08887
• Purity: 90% (SDS-PAGE) Endotoxin: 1EU/ug (LAL).
• Form: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.