KLK10, also known as kallikrein-10, is belong to the subgroup of serine proteases encompassing fifteen homologous members. This protein is widely expressed in normal human organs, for example breast, prostate, thyroid, testis, ovary, and gastrointestinal tract. Interestingly, it is highly expressed in the islets of Langerhans in human pancreas. Also, it is detectable in many biological fluids, including milk, seminal plasma, amniotic fluid, serum, and cerebrospinal fluid. In spite of its unknown physiological functions, the implications of KLK10 in various diseases have been explored. Early studies have shown that this expression is dramatically down-regulated in breast and testicular germ-cell tumors. It is secreted and may play a role in suppression of tumorigenesis in breast. Description: Recombinant protein corresponding to aa34-276 of human KLK10, fused to His-tag at C-terminus, expressed in Baculovirus Molecular Weight: ~27.8kD (252aa), ~28-40kD (SDS-PAGE under reducing conditions) Endotoxin: <0.1EU/1ug (LAL) AA Sequence: ADPALLPQND TRLDPEAYGS PCARGSQPWQ VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH LLLLQGEQLR RTTRSVVHPK YHQGSGPILP RRTDEHDLML LKLARPVVLG PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR RVKYNKGLTC SSITILSPKE CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ GILSWGVYPC GSAQHPAVYT QICKYMSWIN KVIRSNHHHH HH Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
