Maclura pomifera agglutinin or lectin (MPA/MPL) is tetrameric plant protein purified by fractionation. MPA has a molecular weight of about 44,000 and consists of four subunits. It has an isoelectric point between pH 4.8 and pH 5.3, and blood group specificity towards A, B, and O (-SA). This lectin has a high affinity for tumor-associated T-antigen disaccharide (Galbeta1,3GalNAcalpha, ) and many O-linked glycopeptide structures. The structure of Galbeta1,3GalNAcalpha, occurs on the surface of tumor cells as a mucin-associated antigenic marker, termed as T-antigen. It is also the central element in O-linked glycopeptide structures on other mammalian glycoproteins. Source: Osage orange Blood Specificity: A, B, O (-SA) Sugar Specificity: Galbeta, 3GalNAc Inhibitory Carbohydrate: Galactose Divalent Ions: None Required Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
44
Purity:
Semi-Pure
Form:
Supplied as a lyophilized powder.
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