The outbreak of African Swine Fever Virus (ASFV) that has devastated the Chinese pork industry and resulted in over 300,000 pigs being culled is continuing to spread across Asia with new reports in South Korea, Philippines, Vietnam, Laos and Cambodia. There are also further outbreaks of ASFV in Europe with Slovakia becoming the 10th country in Europe to have a confirmed case of ASFV. Its been estimated that this disease will wipe out 20% of world meat protein by years end. African Swine Fever Virus (ASFV) is a highly contagious DNA virus that causes high mortality and is transmitted through direct contact with an infected pig, contaminated feed or through the bite of an infected tick. ASFV isolates can vary in virulence from highly pathogenic strains that cause acute disease and high mortality (90-100%) to low-virulence isolates that present similar but less intense symptoms making the disease chronic and difficult to diagnose. There is no vaccine or treatment. The genome of ASFV is very large and complex, consisting of over 150 genes with 22 different genotypes. Several immunogenic viral antigens have been identified, including p30 which is one of the most antigenic structural proteins involved in ASFV entry and is expressed very early on in infection (2-4 hours post-infection) (Zhang et. al., 2017). Research has shown that with low-virulence strains, virus shedding and antibodies to the virus can persist for months after infection. ASFV can be diagnosed by virus isolation, ELISA, immunofluorescence or PCR. Clinical samples used for testing are lymph nodes, kidneys, spleen, lung, blood and serum. The simultaneous detection of both antigens and antibodies is recommended in order to identify the presence of potentially chronic infections that continue to spread the disease. Recombinant protein corresponding to African Swine Fever Virus (ASFV) p30, fused to His-Tag, expressed in insect cells. Molecular Weight: ~32kD Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
32
Purity:
85% (SDS-PAGE)
Form:
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
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