IL-10, Recombinant, Human, aa19-178, His-Tag
Catalog Number:
USB-532323
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| Article Name: | IL-10, Recombinant, Human, aa19-178, His-Tag |
| Biozol Catalog Number: | USB-532323 |
| Supplier Catalog Number: | 532323 |
| Alternative Catalog Number: | USB-532323-50,USB-532323-100 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| IL-10, also known as Interleukin-10, is an anti-inflammatory cytokine. It inhibits the synthesis of pro-inflammatory cytokines like IFN-gamma, IL2, IL3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. This protein has effects in immunoregulation and inflammation and down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. This protein controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. Recombinant protein corresponding to aa19-178 from human IL-10, fused to His-Tag, expressed in Baculovirus. Molecular Weight: ~19.4kD (166aa) Biological Activity: Measured in a cell proliferation assay using MC/9 mouse mast cells. The ED50 range < 5 ng/ml. Amino Acid Sequence: SPGQGTQSEN SCTHFPGNLP NMLRDLRDAF SRVKTFFQMK DQLDNLLLKE SLLEDFKGYL GCQALSEMIQ FYLEEVMPQA ENQDPDIKAH VNSLGENLKT LRLRLRRCHR FLPCENKSKA VEQVKNAFNK LQEKGIYKAM SEFDIFINYI EAYMTMKIRN HHHHHH Applications: Suitable for use in Bioactivity and SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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