Thrombopoietin, Recombinant, Mouse, aa22-356, His-Tag
Catalog Number:
USB-532385
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| Article Name: | Thrombopoietin, Recombinant, Mouse, aa22-356, His-Tag |
| Biozol Catalog Number: | USB-532385 |
| Supplier Catalog Number: | 532385 |
| Alternative Catalog Number: | USB-532385-50,USB-532385-100 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Megakaryocytopoiesis is the cellular development process that leads to platelet production. It is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Recombinant protein corresponding to aa22-356 from mouse Thrombopoietin, fused to His-Tag, at C-terminal, expressed in HEK293. Molecular Weight: ~36.4kD (341aa) Biological Activity: Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 range < 4 ng/ml. Amino Acid Sequence: SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKFPNRTSG LLETNFSVTA RTAGPGLLSR LQGFRVKITP GQLNQTSRSP VQISGYLNRT HGPVNGTHGL FAGTSLQTLE ASDISPGAFN KGSLAFNLQG GLPPSPSLAP DGHTPFPPSP ALPTTHGSPP QLHPLFPDPS TTMPNSTAPH PVTMYPHPRN LSQETHHHHH H Applications: Suitable for use in Bioactivity and SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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