TRANCE/RANK L/TNFSF11, Recombinant, Mouse, aa158-316
Catalog Number:
USB-532392
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| Article Name: | TRANCE/RANK L/TNFSF11, Recombinant, Mouse, aa158-316 |
| Biozol Catalog Number: | USB-532392 |
| Supplier Catalog Number: | 532392 |
| Alternative Catalog Number: | USB-532392-50,USB-532392-100 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| Tnfsf11, also known as tumor necrosis factor ligand superfamily member 11, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. Tnfsf11 also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation. Tnfsf11 is important in bone metabolism. This natural and necessary surface-bound molecule (also known as CD254) found on osteoblasts serves to activate osteoclasts, which are the cells involved in bone resorption. Recombinant protein corresponding to aa158-316 from mouse TRANCE/RANK L/TNFSF11B, expressed in E. coli. Molecular Weight: ~17.9 kD (160aa), confirmed by MALDI-TOF Biological Activity: Measured in a osteoclast differentiation assay using RAW 264.7 mouse monocyte/macrophage cells. The ED50 range < 2ng/ml. Amino Acid Sequence: MKPEAQPFAH LTINAASIPS GSHKVTLSSW YHDRGWAKIS NMTLSNGKLR VNQDGFYYLY ANICFRHHET SGSVPTDYLQ LMVYVVKTSI KIPSSHNLMK GGSTKNWSGN SEFHFYSINV GGFFKLRAGE EISIQVSNPS LLDPDQDATY FGAFKVQDID Applications: Suitable for use in Bioactivity and SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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