CD38, Recombinant, Human, aa43-300, His-Tag
Catalog Number:
USB-544230
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| Article Name: | CD38, Recombinant, Human, aa43-300, His-Tag |
| Biozol Catalog Number: | USB-544230 |
| Supplier Catalog Number: | 544230 |
| Alternative Catalog Number: | USB-544230-100 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| CD38, also known as ADP-ribosyl cyclase, is a Type II integral membrane protein. The enzyme is able to transform NAD(P)+ into three different products with calcium mobilizing ability, cyclic ADP-ribose, NAADP+ , and ADP-ribose 3. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells 1, 4. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells 5, 6. Source: Recombinant protein corresponding to aa43-300 from human CD38, fused to His-Tag at C-terminal, expressed in a HEK293 cells. Molecular Weight: ~31kD Applications: Suitable for the use in study of protein binding and for screening small molecules and antibodies. Other applications not tested. Assay Conditions: Add CD38 enzyme to 50ul reaction mix containing NGD+ (Nicotinamide Guanine Dinucleotide). Incubate 4 min at room temperature. Read fluorescence (delta exc= 300nm, delta em= 410nm). Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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