IDO1, Recombinant, Human, aa2-403, His-Tag
Catalog Number:
USB-544294
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| Article Name: | IDO1, Recombinant, Human, aa2-403, His-Tag |
| Biozol Catalog Number: | USB-544294 |
| Supplier Catalog Number: | 544294 |
| Alternative Catalog Number: | USB-544294-50 |
| Manufacturer: | US Biological |
| Category: | Molekularbiologie |
| IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders. Source: Recombinant protein corresponding to aa2-403 from human IDO1, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~46kD Assay Conditions: IDO1 activity was confirmed using the IDO1 Inhibitor Screening BioAssay(TM) Kit and following the protocol provided with the kit. Applications: Suitable for use in the study of enzyme kinetics, substrate specificity, and screening inhibitors. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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